https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Anti-Leukaemic Activity of Rilpivirine Is Mediated by Aurora A Kinase Inhibition https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51640 Wed 28 Feb 2024 15:44:33 AEDT ]]> Cancer risk in patients with diverticular disease: A nationwide cohort study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50276 Wed 28 Feb 2024 15:44:15 AEDT ]]> Are the physical environments of treatment centres meeting recommendations for patient-centred care? Perceptions of haematological cancer patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45263 n = 165), almost one-quarter (24%) agreed that the physical environment of the hospital affected their mood or well-being. Patients who disagreed that the hospital was a comfortable temperature or agreed that waiting rooms were crowded had significantly higher odds of reporting that the treatment environment affected their mood or wellbeing. Implementing systems to reduce overcrowding in waiting rooms and increasing patient control over personal temperature in clinics may be the most effective strategies to improve patient wellbeing.]]> Wed 26 Oct 2022 15:42:21 AEDT ]]> Cancer proteomics and the elusive diagnostic biomarkers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46956 Wed 19 Jul 2023 14:21:24 AEST ]]> Clinical trials of medicinal cannabis for appetite-related symptoms from advanced cancer: a survey of preferences, attitudes and beliefs among patients willing to consider participation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29481 n = 144, 71%), followed by mouth spray (n = 84, 42%) and vaporiser (n = 83, 41%). Explanations for preferences (n = 134) most commonly cited convenience (n = 66; 49%). A total of 82% (n = 168) of respondents indicated that they had no trial-related concerns, but a small number volunteered concerns about adverse effects (n= 14) or wanted more information/advice (n = 8). Six respondents volunteered a belief that cannabis might cure cancer, while two wanted assurance of efficacy before participating in a trial. Conclusion: Justification of modes other than tablets/capsules and variable understanding about cannabis and trials will need addressing in trial-related information to optimise recruitment and ensure that consent is properly informed.]]> Wed 17 Nov 2021 16:32:30 AEDT ]]> Clinicopathological significance of nerves in esophageal cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37859 P = 0.04). The surrounding or invasion of nerves by cancer cells (perineural invasion) was detected in 12% of esophageal cancers and was associated with reduced survival (P = 0.04). Nerves were found to express the following receptors for nerve growth factor (NGF): neurotrophic receptor tyrosine kinase 1 and nerve growth factor receptor. An association was suggested between high production of NGF by cancer cells and the presence of nerves (P = 0.02). In vitro, NGF production in esophageal cancer cells was shown by Western blot, and esophageal cancer cells were able to induce neurite outgrowth in the PC12 neuronal cells. The neurotrophic activity of esophageal cancer cells was inhibited by anti-NGF blocking antibodies. Together, these data suggest that innervation is a feature in esophageal cancers that may be driven by cancer cell-released NGF.]]> Wed 17 Nov 2021 16:31:21 AEDT ]]> Co-worker perceptions of return-to-work opportunities for Japanese cancer survivors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32743 Return-to-Work (RTW) opportunities for colleagues with cancer-related symptoms and/or treatment side effects in Japan. Methods: We conducted an online, cross-sectional survey of 3710 employed Japanese individuals of working age. Colleagues' perceptions of RTW opportunities for cancer survivors were examined (using a Japanese questionnaire), along with workplace factors such as job demand, job control and workplace social support (using the Brief Job Stress Questionnaire). Associations between workplace factors and RTW opportunities were evaluated using multiple logistic regression analysis, with participants stratified in tertiles (low, middle and high) according to their levels of workplace social support and job control. Results: Colleagues' perceptions of inadequate RTW opportunities were associated with low workplace social support (middle tertile: Odds Ratio [OR] 1.22, 95% Confidence Interval [CI] : 1.08-1.36; low tertile: OR 1.43, 95%CI: 1.30-1.57; p for trend < 0.01); low levels of job control (middle tertile: OR 1.27, 95%CI: 1.06-1.50; low tertile: OR 1.91, 95%CI: 1.64-2.21; p for trend < 0.01); and no prior experience working with a cancer survivor (OR 2.08, 95%CI: 1.83-2.31). Conclusions: This study suggests that workplace factors and prior experience of working with a cancer survivor may affect a colleagues' perception of RTW opportunities in Japanese workplaces. Consideration of workplace social factors (workplace support and job control), as well as increased openness and awareness of the particular needs of cancer survivors, is therefore essential to facilitate successful RTW in Japan, as elsewhere.]]> Wed 17 Nov 2021 16:29:12 AEDT ]]> Community-identified recommendations to enhance cancer survivorship for Aboriginal and Torres Strait Islander people https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32826 Wed 17 Nov 2021 16:29:05 AEDT ]]> Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43214 Wed 14 Sep 2022 14:34:31 AEST ]]> Barriers and enablers to implementing telehealth consultations in psycho-oncology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49671 Wed 14 Jun 2023 19:08:00 AEST ]]> A Mixed-Method, Multi-Perspective Investigation of Barriers to Participation in Mindfulness-Based Cancer Recovery https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49908 Wed 14 Jun 2023 14:41:41 AEST ]]> Acceptability and appropriateness of a clinical pathway for managing anxiety and depression in cancer patients: a mixed methods study of staff perspectives https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40280 Wed 13 Mar 2024 08:58:30 AEDT ]]> A cross-sectional study of agreement between the Hospital Anxiety and Depression Scale and patient- and radiation oncologist-reported single-item assessment of depression and anxiety https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33202 Wed 12 Sep 2018 15:47:16 AEST ]]> A qualitative investigation of health care professionals', patients' and partners' views on psychosocial issues and related interventions for couples coping with cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21008 Wed 11 Apr 2018 17:02:34 AEST ]]> Cancer survivors' psychosocial outcomes: a population-based investigation of anxiety, depression and unmet needs at six to twelve months post-diagnosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12741 Wed 11 Apr 2018 16:32:46 AEST ]]> Checkpoint immunotherapy for cancer: superior survival, unaccustomed toxicities https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27041 Wed 11 Apr 2018 16:32:14 AEST ]]> Clinician-led improvement in cancer care (CLICC) - testing a multifaceted implementation strategy to increase evidence-based prostate cancer care: phased randomised controlled trial - study protocol https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16763 Wed 11 Apr 2018 15:41:59 AEST ]]> An introduction to the intensity-modulated radiation therapy (IMRT) techniques, tomotherapy, and VMAT https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9510 Wed 11 Apr 2018 15:11:08 AEST ]]> Beating the blues after cancer: randomised controlled trial of a tele-based psychological intervention for high distress patients and carers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7313 Wed 11 Apr 2018 15:05:43 AEST ]]> Antioxidant therapies for neurodegenerative diseases: mechanisms, current trends, and perspectives https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17333 Wed 11 Apr 2018 14:41:13 AEST ]]> Albumin-micelles via a one-pot technology platform for the delivery of drugs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19522 Wed 11 Apr 2018 13:22:24 AEST ]]> Advancing the evidence base in cancer: psychosocial multicenter trials https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14385 Wed 11 Apr 2018 13:18:08 AEST ]]> Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24864 Wed 11 Apr 2018 12:41:17 AEST ]]> Cancer patients' willingness to answer survey questions about life expectancy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14301 Wed 11 Apr 2018 12:34:58 AEST ]]> Cancer biomarker discovery: the entropic hallmark https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9568 Wed 11 Apr 2018 11:52:59 AEST ]]> BCL-2 family isoforms in apoptosis and cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36748 Wed 10 Nov 2021 15:04:41 AEDT ]]> Combined burden and functional impact tests for cancer driver discovery using DriverPower https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55011 Wed 03 Apr 2024 10:12:43 AEDT ]]> Change in health-related quality of life among individuals with cancer undergoing smoking cessation treatment involving varenicline https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48620 Tue 28 Mar 2023 10:04:21 AEDT ]]> Assessing patients' experiences of cancer care across the treatment pathway: a mapping review of recent psychosocial cancer care publications https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36524 Tue 26 May 2020 14:30:48 AEST ]]> Are we missing the Institute of Medicine's mark? A systematic review of patient-reported outcome measures assessing quality of patient-centred cancer care https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16084 Tue 24 Aug 2021 14:27:47 AEST ]]> Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51615 Tue 12 Sep 2023 13:50:05 AEST ]]> Clinical Progress in Gold Nanoparticle (GNP)-mediated Photothermal Cancer Therapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51604 Tue 12 Sep 2023 13:34:49 AEST ]]> Analysis of post-translational modifications of Fat1 cadherin https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15178 Tue 11 Dec 2018 16:37:06 AEDT ]]> Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38190 Tue 10 Aug 2021 16:00:40 AEST ]]> Acceptability of a touch screen tablet psychosocial survey administered to radiation therapy patients in Japan https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23969 Thu 28 Oct 2021 13:03:18 AEDT ]]> A tiered multidisciplinary approach to the psychosocial care of adult cancer patients integrated into routine care: the PROMPT study (a cluster-randomised controlled trial) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33201 Thu 28 Oct 2021 13:03:01 AEDT ]]> A simple filter model to guide the allocation of healthcare resources for improving the treatment of depression among cancer patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32796 Thu 28 Oct 2021 13:02:57 AEDT ]]> Access to cytotoxic medicines by children with cancer: a focus on low and middle income countries https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24082 Thu 28 Oct 2021 13:02:20 AEDT ]]> Access to clinical trials among oncology patients: results of a cross sectional survey https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30163 Thu 28 Oct 2021 13:02:14 AEDT ]]> A p53-responsive miRNA network promotes cancer cell quiescence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35745 chromosome 9 open reading frame 3 gene that was transcriptionally activated by p53. Similarly, the host gene of miRNA-455-3p, collagen alpha-1 (XXVII) chain, was also a p53 transcriptional target. Collectively, our results identify miRNA-27b-3p and miRNA-455-3p as important regulators of cancer cell quiescence in response to p53 and suggest that manipulating miRNA-27b-3p and miRNA-455-3p may constitute novel therapeutic avenues for improving outcomes of cancer treatment. Significance: Two novel p53-responsive microRNAs whose distinct mechanisms of action both stabilize p27 to promote cell quiescence and may serve as therapeutic avenues for improving outcomes of cancer treatment.]]> Thu 28 Oct 2021 12:36:09 AEDT ]]> Continuous inappropriate use of serum tumour markers (letter) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:567 Thu 25 Jul 2013 09:10:39 AEST ]]> Clinical accuracy of the MedGemt indirect calorimeter for measuring resting energy expenditure in cancer patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:525 Thu 25 Jul 2013 09:10:31 AEST ]]> Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:461 Thu 25 Jul 2013 09:09:54 AEST ]]> Contraceptive use and contraceptive counselling interventions for women of reproductive age with cancer: a systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51176 Thu 24 Aug 2023 14:31:05 AEST ]]> Application of chitosan and its derivatives in nanocarrier based pulmonary drug delivery systems https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33589 Thu 22 Nov 2018 13:41:25 AEDT ]]> Characterization of prostate cancer using diffusion tensor imaging: a new perspective https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38735 Thu 20 Jan 2022 14:53:08 AEDT ]]> A review of natural therapies potentially relevant in triple negative breast cancer aimed at targeting cancer cell vulnerabilities https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38357 Thu 09 Sep 2021 12:21:31 AEST ]]> Cancer patients spend more time at home and more often die at home with advance care planning conversations in primary health care: a retrospective observational cohort study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51478 Thu 07 Sep 2023 10:53:04 AEST ]]> Cardiovascular outcomes of cancer patients in rural Australia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51481 Thu 07 Sep 2023 10:51:46 AEST ]]> Cancer incidence and mortality in Australia from 2020 to 2044 and an exploratory analysis of the potential effect of treatment delays during the COVID-19 pandemic: a statistical modelling study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51477 Thu 07 Sep 2023 10:46:14 AEST ]]> Access to care and impacts of cancer on daily life: do they differ for metropolitan versus regional hematological cancer survivors? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20258 Thu 01 Aug 2019 17:13:04 AEST ]]> Anxiety and depression among haematological cancer patients attending treatment centres: prevalence and predictors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20063 Thu 01 Aug 2019 17:12:24 AEST ]]> All's well that ends well?: quality of life and physical symptom clusters in long-term cancer survivors across cancer types https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13559 Sat 24 Mar 2018 10:36:16 AEDT ]]> Are we there yet?: the state of the evidence base for guidelines on breaking bad news to cancer patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7283 Sat 24 Mar 2018 08:42:12 AEDT ]]> A commercial nutraceutical mix metabolic cell-support (MC-S™) inhibits proliferation of cancer cell lines in vitro https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8417 Sat 24 Mar 2018 08:40:52 AEDT ]]> Brief assessment of adult cancer patients' perceived needs: development and validation of the 34-item Supportive Care Needs Survey (SCNS-SF34) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7004 Sat 24 Mar 2018 08:37:50 AEDT ]]> Are Australian oncology health professionals burning out?: a view from the trenches https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7125 Sat 24 Mar 2018 08:34:11 AEDT ]]> Clinical accuracy of the MedGem™ indirect calorimeter for measuring resting energy expenditure in cancer patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1643 Sat 24 Mar 2018 08:30:38 AEDT ]]> Can personal health record booklets improve cancer screening behaviours? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1412 Sat 24 Mar 2018 08:28:15 AEDT ]]> Addressing the needs of caregivers of cancer patients in general practice: a complex intervention https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11271 Sat 24 Mar 2018 08:10:49 AEDT ]]> A systematic review of psychosocial interventions for men with prostate cancer and their partners https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12268 Sat 24 Mar 2018 08:10:13 AEDT ]]> "You need something like this to give you guidelines on what to do": patients' and partners' use and perceptions of a self-directed coping skills training resource https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19031 Sat 24 Mar 2018 08:05:26 AEDT ]]> Baseline depression predicts malnutrition in head and neck cancer patients undergoing radiotherapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18232 Sat 24 Mar 2018 08:04:52 AEDT ]]> A longitudinal analysis of symptom clusters in cancer patients and their sociodemographic predictors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18329 Sat 24 Mar 2018 08:04:49 AEDT ]]> A tailored, supportive care intervention using systematic assessment designed for people with inoperable lung cancer: a randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18207 0.10), although change score analysis indicated a relative benefit from the intervention for unmet symptom needs at 8 and 12weeks post-assessment (effect size=0.55 and 0.40, respectively). Conclusion: Although a novel approach, the hypothesis that the intervention would benefit perceived unmet needs, psychological morbidity, distress and health-related quality of life was not supported overall.]]> Sat 24 Mar 2018 08:04:37 AEDT ]]> Common variants of xeroderma pigmentosum genes and prostate cancer risk https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19105 Sat 24 Mar 2018 07:55:58 AEDT ]]> Clinical perspectives on hereditary hemochromatosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5556 Sat 24 Mar 2018 07:49:12 AEDT ]]> Automatic colonic polyp detection by the mapping using regional unit sphere https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5964 Sat 24 Mar 2018 07:47:27 AEDT ]]> Computerised assessment of quality of life in oncology patients and carers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5338 Sat 24 Mar 2018 07:45:55 AEDT ]]> An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:130 Sat 24 Mar 2018 07:43:12 AEDT ]]> Basal lamina visualization using color image processing and pattern recognition https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:314 Sat 24 Mar 2018 07:42:41 AEDT ]]> A systematic review and meta-analysis of social cognitive theory-based physical activity and/or nutrition behavior change interventions for cancer survivors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28997 n = 12) revealed a significant intervention effect for physical activity (standardized mean difference (SMD) = 0.33; P < 0.01). Most studies (six out of eight) that targeted dietary change reported significant improvements in at least one aspect of diet quality. No SCT constructs were associated with intervention effects. There were no consistent trends relating to intervention delivery method or whether the intervention targeted single or multiple behaviors. Conclusions: SCT-based interventions demonstrate promise in improving physical activity and diet behavior in cancer survivors, using a range of intervention delivery modes. Further work is required to understand how and why these interventions offer promise for improving behavior. Implications for Cancer Survivors: SCT-based interventions targeting diet or physical activity are safe and result in meaningful changes to diet and physical activity behavior that can result in health improvements.]]> Sat 24 Mar 2018 07:29:24 AEDT ]]> A best practice dietetic service for rural patients with cancer undergoing chemotherapy: a pilot of a pseudo-randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4910 Sat 24 Mar 2018 07:22:59 AEDT ]]> Cancer incidence and mortality in aircraft maintenance workers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4616 Sat 24 Mar 2018 07:21:54 AEDT ]]> Clozapine, cancer chemotherapy and neutropenia - dilemmas in management https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23734 Sat 24 Mar 2018 07:16:54 AEDT ]]> Cancer incidence and mortality in people aged less than 75 years: changes in Australia over the period 1987-2007 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23698 Sat 24 Mar 2018 07:13:26 AEDT ]]> A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23064 combined=3.32 x 10(-15), OR=1.72) and independent from rs3731217, the previously reported ALL-associated variant in this region. Of correlated SNPs tagged by this locus, only rs662463 is significant in African Americans, suggesting it is a plausible causative variant. Functional analysis shows that rs662463 is a cis-eQTL for CDKN2B, with the risk allele associated with lower expression, and suggests that rs662463 influences BCP-ALL risk by regulating CDKN2B expression through CEBPB signalling. Functional analysis of rs3731217 suggests it is associated with BCP-ALL by acting within a splicing regulatory element determining CDKN2A exon 3 usage (P=0.01). These findings provide new insights into the critical role of the CDKN2 locus in BCP-ALL aetiology.]]> Sat 24 Mar 2018 07:12:28 AEDT ]]> A retrospective analysis of hospital treatment expenditures among young and middle age patients with cancer, 2013-2017 under health reform https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38345 Mon 30 Aug 2021 15:31:32 AEST ]]> Can hemp help? Low-THC cannabis and non-THC cannabinoids for the treatment of cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38260 9-tetrahydrocannabinol (∆9-THC). Evidence is emerging for the therapeutic benefits of cannabis in the treatment of neurological and neurodegenerative diseases, with potential efficacy as an analgesic and antiemetic for the management of cancer-related pain and treatment-related nausea and vomiting, respectively. An increasing number of preclinical studies have established that ∆9-THC can inhibit the growth and proliferation of cancerous cells through the modulation of cannabinoid receptors (CB1R and CB2R), but clinical confirmation remains lacking. In parallel, the anti-cancer properties of non-THC cannabinoids, such as cannabidiol (CBD), are linked to the modulation of non-CB1R/CB2R G-protein-coupled receptors, neurotransmitter receptors, and ligand-regulated transcription factors, which together modulate oncogenic signalling and redox homeostasis. Additional evidence has also demonstrated the anti-inflammatory properties of cannabinoids, and this may prove relevant in the context of peritumoural oedema and the tumour immune microenvironment. This review aims to document the emerging mechanisms of anti-cancer actions of non-THC cannabinoids.]]> Mon 29 Jan 2024 17:45:13 AEDT ]]> A systematic review of barriers to optimal outpatient specialist services for individuals with prevalent chronic diseases: what are the unique and common barriers experienced by patients in high income countries? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24797 Mon 23 Sep 2019 14:21:55 AEST ]]> Actin crosslinking protein α-actinin-4 (ACTN4) regulates receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33913 Mon 23 Sep 2019 10:51:36 AEST ]]> Complementary and alternative therapies in the palliative setting https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51100 Mon 21 Aug 2023 15:06:10 AEST ]]> A comparison of techniques for the recovery of schistosome eggs in autopsy material https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34156 Mon 18 Mar 2019 11:44:59 AEDT ]]> Awareness of alcohol as a risk factor for cancer is associated with public support for alcohol policies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43018 Mon 12 Sep 2022 09:36:26 AEST ]]> Axin2(+) endometrial stem cells: the source of endometrial regeneration and cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43020 Mon 12 Sep 2022 09:32:47 AEST ]]> Continued smoking after a cancer diagnosis: a longitudinal study of intentions and attempts to quit https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36960 Mon 03 Jul 2023 14:35:23 AEST ]]> Access to support for Australian cancer caregivers: in-depth qualitative interviews exploring barriers and preferences for support https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40158 Fri 29 Jul 2022 11:52:17 AEST ]]> A randomised, double blind, placebo-controlled trial of megestrol acetate or dexamethasone in treating symptomatic anorexia in people with advanced cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45413 Fri 28 Oct 2022 12:09:54 AEDT ]]> Barriers and facilitators to community-based psycho-oncology services: a qualitative study of health professionals attitudes to the feasibility and acceptability of a shared care model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36949 Fri 24 Jul 2020 16:33:42 AEST ]]> Chinese version of the Cancer Support Person's Unmet Needs Survey-Sort Form: A psychometric study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49487 Fri 19 May 2023 09:34:55 AEST ]]> A qualitative study investigating Australian cancer service outpatients’ experience of distress screening and management: what is the personal relevance, acceptability and improvement opportunities from patient perspectives? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47065 Fri 19 Apr 2024 14:59:47 AEST ]]> Adult patient communication experiences with nurses in cancer care settings: a qualitative study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43396 Fri 16 Sep 2022 09:58:32 AEST ]]> Apples to apples? Comparison of the measurement properties of hospital anxiety and depression-anxiety subscale (HADS-A)... https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44472 Fri 14 Oct 2022 08:43:40 AEDT ]]> Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47334 Fri 13 Jan 2023 11:55:34 AEDT ]]> Brain cancer patient and support persons’ experiences of psychosocial care: a mapping of research outputs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49396 Fri 12 May 2023 14:34:08 AEST ]]> Agreement between a single-item measure of anxiety and depression and the hospital anxiety and depression scale: a cross-sectional study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36657 Fri 10 Mar 2023 19:03:42 AEDT ]]> Cancer Risks for PMS2-Associated Lynch Syndrome. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43006 Fri 09 Sep 2022 14:17:25 AEST ]]> A cross-sectional audit of current practices and areas for improvement of distress screening and management in Australian cancer services: is there a will and a way to improve? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46949 Fri 09 Dec 2022 14:35:32 AEDT ]]> Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51500 Fri 08 Sep 2023 11:56:25 AEST ]]> Considerations for Evaluating the Introduction of New Cancer Screening Technology: Use of Interval Cancers to Assess Potential Benefits and Harms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50771 Fri 04 Aug 2023 15:32:56 AEST ]]>